This role will work in close collaboration with an internal bioinformatician who designs oligo sequences, with primary responsibility for chemical modification strategy, manufacturability, and chemistry-driven optimization. The role will also collaborate with the IP team to support invention disclosures and patent filings for novel chemistries.
Key Responsibilities
- Lead and optimize chemical modification strategies for oligonucleotides used in in vitro and in vivo studies
- Oversee CROs producing oligonucleotides (scope, timelines, troubleshooting, QC/release review)
- Own and maintain the oligonucleotide database (sequence/modification tracking, lot history, QC documentation, traceability)
- Drive novel chemistry innovation (modifications, linkers, conjugation strategies, delivery-enabling chemistries)
- Support development of bispecific siRNA and other complex oligo architectures
- Collaborate cross-functionally with biology, bioinformatics, and program teams to ensure high-quality delivery of oligo materials
- Partner with the IP/legal team to document innovations and support patent filings (invention disclosures, data summaries, chemistry descriptions)
- Review and interpret analytical data (HPLC, LC-MS) and ensure fit-for-purpose QC standards
- Identify process improvements for better yield, purity, turnaround times and lower cost of goods
- Establish in house capabilities for small and medium scale oligo platform
- This list is not exhaustive and is subject to change and periodic review. All employees are expected to be flexible with their duties and support business activities as and when needed.